Charlie Gard - A Treatment Option

Here is something left of field, very safe, and available, that could be used to help Charlie Gard, with no downside, right where he is now.

WHY MIGHT HIGH DOSE IV B12 MAKE A DIFFERENCE TO CHARLIE GARD’S CONDITION? (See page 3 of PDF)
We have sent letters to The Pope, to Professor Muntoni, a neurologist at Great Ormond Street Hospital, and to Professor Hirano, the US expert on mitochondrial diseases. PLEASE HELP US TO MAKE THIS INFORMATION KNOWN.

WHY MIGHT HIGH DOSE IV B12 MAKE A DIFFERENCE TO CHARLIE GARD’S CONDITION?

Here is something left of field, very safe, and available, that could be used to help Charlie Gard, with no downside, right where he is now.

VIEW PDF: HIGH DOSE IV VITAMIN B12 AS METHYLCOBALAMIN: REFS: MECHANISMS OF NEUROLOGICAL & CLINICAL IMPACT

Letter to The Pope


A POSSIBLE LEFT-OF-FIELD, FORGOTTEN TREATMENT OPTION FOR CHARLIE GARD THAT IS SAFE & COULD BE DONE NOW IN GOSH OR ANYWHERE IN EUROPE, NOT LEAST ROME.

                                                              Oxford,    14th July 2017 

Your Holiness Papa Francesco,

                                                           I am a medical researcher, for a UK registered charity, affiliated to St Catherine’s College, Oxford, and currently working with the William Harvey Institute, part of Barts medical school on a B12 for sepsis treatment pre-clinical study. 

My field of interest is vitamin B12,  & cancer, septic shock, sepsis/inflammation, antibiotic resistance, with a view to its clinical application.

In respect of the Charlie Gard case, I believe that there is a third medical treatment option, that no-one in the international debate, or caring for the child is aware of.

Erase una vez…. en la epoca de los 195o hasta 1980, en los paises pobres,  como Rusia, Portugal, Sud America, Mejico, y en los menos pobres, come Espana, Francia y, principalmente, en Italia, los medicos usaban la vitamina B12, -que es mas que una vitamina-, para tratar todo tipo de problemas.

En el documento que he compilado, [tal vez con demasiado prisa, pues la cosa es urgente-vease abajo], se puede ver que el uso clinico de la vitamina B12 en dosis alta y  por ruta parenteral,  para tratar, no solo la insuficiencia, sino, por ejemplo,  problemas como la  epilepsia, -problema que tiene Charlie G- el mal crecimiento, problemas neurolojicos, problemas del corazon, de dolor insoportable del cancer avanzado, y problemas de los bebes prematuros, era una cosa completamente normal, efectiva, que no costaba mucho dinero.

Luego al mejorar la economia de estos paises parece ser que todo esto se olvido. 

Pero la historia esta bien documentada en la literatura medica y cientifica, aunque, como a menudo las publicaciones estan escritas en idiomas distintos al ingles, tampoco a penas se conoce todo esto. hoy dia los medicos lo ignoran.
[Yo tengo la suerte de poder leer varios idiomas. Asi que descubri todo esto hace tiempo].

En este documento abajo doy muchas referencias sobre todo esto, y ademas trato de explicar muy brevemente porque hemos aqui un posible tratamiento para Charlie Gard, que tal vez, y si Dios quiere, podia salvarle su vida, o al menos mejorar sus problemas y extender su vida, hasta que se pueda hacer algo mas.

Este tratamiento no le haria ningun mal a el bebe, pues nunca ha matado a nadie. [Lo tengo todo muy bien referenciado cientificamente].

Seria cosa muy facil hacerlo en Londres, o en Roma, o donde sea. Y apenas costaria mucho. Pues verdaderamente, al igual que el tratamiento propuesto en el USA, no es una droga.
Pero, al opuesto del tratamiento del USA, el uso de la vitamina B12, en alta dosis, por via parenteral no es nada nuevo.
Luego se sabe que no hay peligro.

En Francia en los ICUs B12 se ha usado ya casi 70 anos como la mejor antidota contra el envenenamiento de cyanuro.

Lo mas importante del tema:
la vitamina B12 es esencial para la sintesis de la DNA y de la rejeneracion mitocondrial.

Solo por esta simple razon valdria muchisimo hacer una prueba clinica con el bebe Charlie Gard, antes de que pierda su vida.
Pero hay mas beneficios de la B12, y lo explico en mi documento.

La cosa es simple.
Pero lo simple se olvida a menudo.
Y entonces padecen los hombres.

La historia de la medicina tiene muchos capitulos donde se ve bien, que las soluciones simples se pueden ignorar por siglos.

Yo se que Su Santidad es un cura que ve las cosas con claridad, sin las sofisticaciones del mundo. Cosa que nos da a todos esperanza. Y es por eso que  os escribo a vos.

Tal vez, Su Santidad pueda compartir este documento con los medicos del Bambino Jesu?
Tal vez ellos puedan hablar de esto con los medicos ingleses en GOSH, si les parece bien?

Es un tratamiento que se podia hacer calladamente, sin prensa, cuando ya no quede mas recursos.
Tal vez en Roma?

Se podia hacer tambien junto al tratamiento Americano, o antes de que viaje el bebe, si se logra, para ayudar a estabilizarlo.
Tal vez  la hora llega demasiado precipitadamente.

Por Favor, Su Santidad, considerad esto bien. Nuestro mundo esta dominado por las drogas farmaceuticas, y se ha olvidado lo que Dios nos ha dado gratis, la B12, gracias a los microbios, que saben hacer una estructura que es la mas complicada quimicamente pero simple, barata y  efectiva.

En el documento tambien, como ejemplo de lo posible clinicamente, cuento un caso de un accidente en el quirofano, en el  cual un protocolio que publique en 2006, para el uso de B12 en alta dosis, restauro a una mujer paralizada en menos de una semana, y le salvo la vida. Claro que esto paso en Morrocco, donde todavia saben el valor de lo simple .

  Le saluda atentamente, y ruega por Su salud, Carmen

Por favor, vease el documento abajo!

Dr Carmen Wheatley
Orthomolecular Oncology (Registered Charity No:1078066)

Letter to Professor Muntoni


Dear Professor Muntoni,

                                              I am affiliated to St Catherine’s College, Oxford, as well as to a UK registered medical charity. 

I am currently collaborating on pre-clinical studies of high dose cobalamin/vitamin B12 for sepsis, with Professors Mauro Perretti and Fulvio d’Acquisto at the Biochemical Pharmacology lab,  William Harvey Institute.

My field of special interest is cobalamin, nitric oxide, and inflammation, as these relate to sepsis and cancer.  [Please see my Researchgate page, if this interests you].

I write, on compassionate grounds,  to call your attention to a third option in the difficult case of Charlie Gard: namely, the use of very high dose intravenous vitamin B12 as methylcobalamin, a therapy which would probably be synergistic with nucleoside replacement therapy, but could also be used on its own, with perhaps similar or even better potential effects.  

A compatriot of yours, whom you may know, Professor Giuseppe Scalabrino, and his group in Milan, have done much work on the effects of cobalamin in the CNS.

 Dr Scalabrino believes, and I concur, that B12 has untapped clinical potential for neurological problems, including seizures. And indeed, for many other conditions, including mitochondrial disease.

I know you may have little time, but if you would be so kind as to look at the first 5 pages of bullet points in the document attached below at your earliest convenience, you may understand why there is something worth exploring here.

Page 3 briefly explains why this approach may be relevant in the case of Charlie Gard. [Agreed: I do not have full details of the extent of his brain damage.]

I do not know whether you are involved in this child’s care. But, if not,  perhaps you may be able to pass my email and document on to other doctors concerned?

If the child is to be left to die, there would seem to be little downside, on compassionate grounds, in doing a trial of IV high dose B12 as methylcobalamin, as a last possible chance before switching off the life support. It can be done at GOSH, if the team is willing to consider this.

Methylcobalamin for injection is available at the necessary concentration, both in the UK, Europe and the USA. I would be happy to help source this.

      I very much hope that this will not be lightly dismissed.

I am not a neurologist. But two years ago I was asked to give advice in the case of a young woman with a cavernous angioma, which was causing seizures that drugs prescribed by Queen’s Square based neurologists failed to control. Surgery was not an option. As a result of interventions I proposed, the cavernous angioma was significantly reduced by a third, in 3 months, and the seizures stopped altogether.

I have had enough such experiences over the years with different, supposedly intractable medical problems, to confirm that sometimes something left of field can work where all else fails, against the odds.

          With my thanks, and kind regards,   Carmen

                              Dr Carmen Wheatley

                                Orthomolecular Oncology,

                             (Registered Charity No:1078066)

Letter to Professor Hirano


Dear Dr Hirano,

                              I am affiliated to St Catherine’s College, Oxford, as well as to a UK registered medical charity. 

I am currently collaborating on pre-clinical studies of high dose cobalamin/vitamin B12 for sepsis, with Professors Mauro Perretti and Fulvio d’Acquisto at the Biochemical Pharmacology lab,  William Harvey Institute.

My field of special interest is cobalamin, nitric oxide, and inflammation, as these relate to sepsis and cancer.  [Please see my Researchgate page, if this interests you].

I write, on compassionate grounds,  to call your attention to a third option in the difficult case of Charlie Gard: explained in the document attached below. 

There is another unconsidered treatment option that may complement your approach, and increase the child’s chances perhaps considerably above 10%: namely, the use of very high dose intravenous vitamin B12 as methylcobalamin, a therapy which would probably be synergistic with nucleoside replacement therapy, but could also be used on its own, with perhaps similar potential effects. However, it is not a case of either or.

Please read the first 5 pages of bullet points and in particular page 3, which explains the rationale for Charlie.

Methylcobalamin for injection is available at the necessary concentration, both in the UK, Europe and the USA. I would be happy to help source this.

      I very much hope that this will not be lightly dismissed.

I am not a neurologist. But two years ago I was asked to give advice in the case of a young woman with a cavernous angioma, which was causing seizures that drugs prescribed by Queen’s Square, London based neurologists failed to control. Surgery was not an option. As a result of interventions I proposed, the cavernous angioma was significantly reduced by a third, in 3 months, and the seizures stopped altogether.

I have had enough such experiences over the years with different, supposedly intractable medical problems, to confirm that sometimes something left of field can work where all else fails, against the odds.

          With my thanks, and kind regards,   Carmen

Dr Carmen Wheatley

Orthomolecular Oncology, (Registered Charity No:1078066)